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Humanitarian diagnostics for sleeping sickness in Uganda

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A key impetus for the invention of a Rapid Diagnostic Test (RDT) for sleeping sickness (also known as human African trypanosomiasis or HAT) was the persuasive advocacy for better ‘field ready tools’ by medical humanitarian agencies such as Médecins Sans Frontières. They were engaged in fighting outbreaks of this disease, which is fatal if untreated, in contexts of weakened health …

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Ultrasound as a diagnostic tool in Brazil: celebrating babies, blurring problems.

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This is a photograph of a publicity for a “street corner” obstetrical ultrasound in Brazil. It proclaims: “ultrasound examinations at low prices.” The advertised “low prices” can be indeed be very low: some clinics charge less than US $10 for an ultrasound examination. The aim such examination is to confirm the existence of a pregnancy, provide reassurance, but above all …

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Diagnostics without diagnosis: RDTs for Sleeping Sickness in Uganda

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Diagnosing sleeping sickness (also known as human African trypanosomiasis (HAT)) is complicated, requiring the alignment of clinical suspicion with serological, parasitological, and molecular confirmation to determine appropriate treatment. Previously, diagnosis was carried out by mobile lab teams which confirmed cases in village screenings and transported patients for treatment. Since cases have declined however, expensive active screening campaigns have been phased …

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Diagnosing trachoma for elimination

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Trachoma is the leading infectious cause of blindness worldwide, caused by ocular infection with the bacterium Chlamydia trachomatis. Trachoma is targeted for elimination as a public health problem by the year 2020. The treatment and prevention strategy to achieve elimination is known as SAFE, and includes: Surgery for in-turned eyelashes, Antibiotics, given as mass drug administration …

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ReEBOV: Developing an Ebola rapid diagnostic test at research ground zero

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In June 2015, as Sierra Leone and Guinea was experiencing new surges in clusters of Ebola virus cases, Nature published a news article asking why an inexpensive test that “could save lives” was not being deployed to the field. Indeed, while it seemed obvious to many policy makers and health experts that Ebola rapid diagnostic tests were urgently needed, the …

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Global Health Diagnostics: Workshop Summary

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On January 17th, 2018, participants from the UK, Europe, and India gathered in Edinburgh for “Investigating Diagnostic Devices in Global Health”, a workshop that also marked the launch of the ERC funded DiaDev project. Hosted by the DiaDev team, Alice Street, Ann Kelly, Nanda Kannuri and Eva Vernooij, the multi-disciplinary workshop …